Protein Details: Voltage-gated Potassium channel-interacting protein 1

Protein ID

ICDB_Pro_1530

Protein Name

Voltage-gated Potassium channel-interacting protein 1

Gene Name

Kcnip1; Kchip1

Organism

Mus musculus (Mouse)

Length

227 amino acids

AlphaFoldDB

AF-Q9JJ57-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents. In vitro; modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface

Sequence

MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDELEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEETFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

146;148;150;152;157;194;196;198;205

Disease

Location

Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.

DOI ID

10.1016/s1044-7431(03)00174-x; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/j.molbrainres.2004.06.024; 10.4161/chan.3.4.9553

RefSeq

NP_001177814.1 [Q9JJ57-1]; NP_001177815.1; NP_001277619.1 [Q9JJ57-3]; NP_081674.2 [Q9JJ57-2]